This is from the Sage Architecture Guide here ;:

partnerportal.sagex3.com/.../architecture_guide_v11.pdf

Antivirus If you install an antivirus protection on Sage X3 servers, we recommend disabling real-time protection on some parts of the Application/Main Process server and Additional Process servers for best performance. Perform scheduled scans on realtime scanning excluded areas overnight when there are few or no users logged on.

Exclude the following directories from real-time protection if active: • The \folders directory on the Application server(s) and all its subdirectories (X3 objects, temp files, trace files, etc.); •

The \runtime directory and its subdirectories (runtime engine, temp files, trace files) on all Process servers (including Main one).