Desktop stopped working

SOLVED

After installing Sage 300 2018 PU7 from PU2, Sage 300 is unable to open. I have checked all possible causes from various threads about a similar problem, but still unable to open Sage 300. I even tried to use the DBSPY and RVSPY to try to trap the error, but there is nothing amiss with the logfiles. There is no antivirus on the Server. I have been troubleshooting this for the whole day and still no end in sight. 

Does anyone have some pointers that I can use?