Hi Martin Brinkerhoff

Since it looks like you are using Sage 50 US edition, I am going to move this post to that Support Group so that other users of this software will see it and can offer you their thoughts and insight.

Multi state payroll can be run in a single Sage 50 company, see this article titled "How to set up multiple state income tax (SIT) withholdings"

Thanks,

Erzsi