yes.  we have had employees in 5 different states at the same time.  It is a bit complicated,  you will need to set up each state unemployment tax as a "user-maintained" payroll tax formula.  On the employees in the other state(s),  set the unemployment  to the correct formula on the "Company Fields" in Maintain Employees.  Hope this helps!

I was needing the unemployment to go to the state of the employer, not the state of the employees.  i would do a work around where i change the withholding state to the state of the employer and run the payroll tax liability report to capture the unemployment amount and then switch it back.