Uninstall old Sage 300 versions after new versions are already installed?

Is it possible to uninstall an older version of Sage 300 if a newer version of the same product is installed?  In our case, we just installed Sage 300 2021 on the same computer that has Sage 300 2018 installed on it.  Now we see both products are listed in our software inventory.  If we uninstall Sage 300 2018, will that break Sage 300 2021?