You can't.  That is how Sage is designed.  The variance amount posts to an account set in Product Line maintenance.

Thank you for your response.  How can I balance the variance in the account set in Product Line maintenance?

What do you mean by "balance"?  I'm not an accountant but it's my understanding this is usually a COGS type account.  If you still have the inventory you've maybe counted the difference early, but if the inventory is gone the variance is where it should be.

The inventory is correct. i.e. 5 cases shipped = 5 cases billed.  However 5 cases received @ $5 but 5 cases billed @ $6.  I am trying to figure out how I can adjust the $1 difference

Adjust where?  The amount should be posted to the GL as a COGS amount.

If you have the inventory on hand and want to make an inventory value adjustment, do that (IA... - old value, + new value), and a GL entry offsetting the difference between the adjustment account to the variance account... but that is not worth doing for small amounts, and impossible if the inventory is already consumed.

IF the goods are still on hand then do a Return of Goods, update, change the price on the purchase order and then do a Receipt of Goods with Invoice.  Otherwise you will need to post the invoice, not the amount of the variance and the GL account it went to. Adjust out the items left on hand and adjust in with correct cost. Note the difference and make a GJ entry taking money out of the inventory adjustment account and putting it into the purchase order variance account.  Note how many items you may have sold and post to COGS account the amount needed to zero out the purchases variance account. That's how I would do it.

Returns won't work properly for some valuation methods (FIFO...) because you don't get to choose the cost tier.

Dat True, needs to be Serial or Lot